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Fabien CRAUSTE

CNRS Senior Research Scientist
Habilité à Diriger des Recherches


MAP5 UMR 8541
Université de Paris
45 rue des Saints Pères, 75270 Paris cedex 06, France

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Phone: (+33)1 76 53 03 34 - Email: 
 

Coordinator of GDR MathSAV (a national research initiative in mathematics, health, life sciences).
Member of the steering committee of AMIES (French Agency for Mathematics in Interaction with Companies and Society).
Member of the MAP5 laboratory initiative MAP1.5, workgroup devoted to the analysis of lab habits and their impact on the environment, relying on the Labos 1point5 initiative.


Research Themes:
 - Biomathematics, Modeling, Delay Equations, Structured Equations, Agent-Based Models
 - Mathematical Immunology (CD8 T cell response, B cell response, cancer immiunotherapy)
 - Cell Population Dynamics


Research Projects:

Project COSMIC
Combatting Disorders of Adaptive Immunity with Systems Medicine
Funded by the ERC
(Marie Sklodowska-Curie Actions)


Project MEMOIRE
Modélisation multi-échelles des réponses immunes T CD8
Funded by the ANR



Former supervisions:
Alexey Koshkin (PhD thesis, 2018-2021)
Ronan Duchesne (PhD thesis, 2016-2019)
Simon Girel (PhD thesis, 2015-2018)
Chloé Audebert (postdoc, 2017-2018)
Marine Jacquier (PhD thesis, 2012-2016)
Xuefeng Gao (postdoc, 2014-2015)
Sotiris Prokopiou (postdoc, 2013-2014)
Floriane Lignet (postdoc, 2013-2014)
Emmanuelle Terry (PhD thesis, 2009-2012)



Publications:
  1. R. Duchesne, A. Guillemin, O. Gandrillon, F. Crauste. Practical identifiability in the frame of nonlinear mixed effects models: the example of the in vitro erythropoiesis . BMC Bioinformatics 22 (478) (2021).
    HAL preprint  article
  2. E. Merino Tejero, D. Lashgari, R. Garcia-Valiente, X. Gao, F. Crauste, P. Robert, M. Meyer-Hermann, M. Rodríguez Martínez, S.M. van Ham, J. Guikema, H. Hoefsloot, A. van Kampen. Multiscale Modeling of Germinal Center Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells Differentiation as Regulated by Antigen Affinity-Based Tfh Cell Help. Front. Immunol. 11, 3805 (2021).
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  3. C. Audebert, D. Laubreton, C. Arpin, O. Gandrillon, J. Marvel, F. Crauste. Investigation of Inter-Individual Variability in CD8 T Cell Responses with Nonlinear Mixed Effects Models. In Silico Biology 14(1-2), 13-39 (2020).
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  4. I. Balelli, C. Pasin, M. Prague, F. Crauste, T. Van Effelterre, V. Bockstal, L. Solforosi, R. Thiébaut. A model for establishment, maintenance and reactivation of the immune response after vaccination against Ebola virus. J. Theor. Biol. 495, 110254 (2020).
    HAL preprint  article
  5. A. Guillemin, R. Duchesne, F. Crauste, S. Gonin-Giraud, O. Gandrillon. Drugs modulating stochastic gene expression affect the erythroid differentiation process. PLoS ONE 14(11): e0225166 (2019).
    HAL preprint  article
  6. R. Duchesne, A. Guillemin, F. Crauste, O. Gandrillon. Calibration, Selection and Identifiability Analysis of a Mathematical Model of the in vitro Erythropoiesis in Normal and Perturbed Contexts. In Silico Biology. 13, 55-69 (2019).
    HAL preprint  article
  7. S. Girel, C. Arpin, J. Marvel, O. Gandrillon, F. Crauste. Model-based assessment of the role of uneven partitioning of molecular content on heterogeneity and regulation of differentiation in CD8 T-cell immune responses. Front. Immunol. 10, 230 (2019).
    HAL preprint  article
  8. K. Grzesik, K. Eng, F. Crauste, S. Battaglia. In Silico Methods for Studying T Cell Biology. Int. Rev. Cell. Mol. Biol. 342, 265-304 (2019).
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  9. L. Boullu, M. Adimy, F. Crauste, L. Pujo-Menjouet. Oscillations and asymptotic convergence for a delay differential equation modeling platelet production. Discrete & Continuous Dynamical Systems - B, 24 (6), 2417-2442 (2019).
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  10. S. Girel, F. Crauste. Existence and stability of periodic solutions of an impulsive differential equation and application to CD8 T-cell differentiation. J. Math. Biol. 76 (7), 1765-1795 (2018).
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  11. L. Barbarroux, Ph. Michel, M. Adimy, F. Crauste. A multiscale model of the CD8 T cell immune response structured by intracellular content. Discrete and Continuous Dynamical Systems Series B 23 (9), 3969-4002 (2018).
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  12. O. Angulo, O. Gandrillon, F. Crauste. Investigating the role of the experimental protocol in phenylhydrazine-induced anemia on mice recovery. J. Theoret. Biol. 437, 286-298 (2018).
    HAL preprint  article
  13. O. Angulo, F. Crauste, JC Lopez-Marcos. Numerical integration of an erythropoiesis model with explicit growth factor dynamics. Journal of Computational and Applied Mathematics 330, 770-782 (2018).
    HAL preprint  article
  14. F. Crauste, J. Mafille, L. Boucinha, S. Djebali, O. Gandrillon, J. Marvel, C. Arpin. Identification of nascent Memory CD8 T cells and modeling of their ontogeny. Cell Systems 4(3), 306-317 (2017).
    HAL preprint  article
  15. L. Barbarroux, P. Michel, M. Adimy, F. Crauste. Multi-scale modeling of the CD8 immune response. AIP Conference Proceedings 1738 (1), 320002 (2016).
    HAL preprint  article
  16. X. Gao, C. Arpin, J. Marvel, S. Prokopiou, O. Gandrillon, F. Crauste. IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8+ T cell-APC: a multiscale modeling study. BMC Systems Biology, 10, 77 (2016).
    HAL preprint  article
  17. M. Jacquier, H.A. Soula, F. Crauste. A mathematical model of leptin resistance. Mathematical Biosciences, 267, 10-23 (2015).
    HAL preprint  article
  18. S. Bernard, F. Crauste. Optimal linear stability condition for scalar differential equations with distributed delay. Discrete and Continuous Dynamical Systems Series B, 20 (7), 1855-1876 (2015).
    HAL preprint  article
  19. F. Crauste, E. Terry, I. Le Mercier, J. Mafi lle, S. Djebali, T. Andrieu, B. Mercier, G. Kaneko, C. Arpin, J. Marvel, O. Gandrillon. Predicting Pathogen-Speci c CD8 T Cell Immune Responses from a Modeling Approach. J. Theor. Biol., 374, 66-82 (2015).
    HAL preprint  article
  20. S. Prokopiou, L. Barbarroux, S. Bernard, J. Mafille, Y. Leverrier, C. Arpin, J. Marvel, O. Gandrillon, F. Crauste. Multiscale modeling of the early CD8 T cell immune response in lymph nodes: an integrative study. Computation, 2(4), 159-181 (2014).
    HAL preprint  article
  21. M. Jacquier, F. Crauste, Ch. Soulage, H. Soula. A predictive model of the dynamics of body weight and food intake in rats submitted to caloric restrictions. PLoS ONE, 9(6): e100073 (2014).
    HAL preprint  article
  22. M. Adimy, F. Crauste. Delay Differential Equations and Autonomous Oscillations in Hematopoietic Stem Cell Dynamics Modeling. Mathematical Modelling of Natural Phenomena, 7 (6), 1-22 (2012).
    HAL preprint  article
  23. E. Terry, J. Marvel, C. Arpin, O. Gandrillon, F. Crauste. Mathematical Model of the primary CD8 T Cell Immune Response: Stability Analysis of a Nonlinear Age-Structured System. Journal of Mathematical Biology, 65, 263-291 (2012).
    HAL preprint  article
  24. S. Fischer, P. Kurbatova, N. Bessonov, O. Gandrillon, V. Volpert, F. Crauste. Modelling erythroblastic islands: using a hybrid model to assess the function of central macrophage. J. Theo. Biol., 298, 92-106 (2012).
    HAL preprint  article
  25. F. Crauste. Equations aux dérivées partielles structurées en âge et équations à retard : Deux exemples d'applications en biologie, MATAPLI, 96, 73-95 (2011).
    article
  26. N. Bessonov, F. Crauste, S. Fischer, P. Kurbatova, V. Volpert. Application of Hybrid Models to Blood Cell Production in the Bone Marrow. Math. Model. Nat. Phenom., 6 (7), 2-12 (2011).
    HAL preprint  article
  27. N. Bessonov, F. Crauste, V. Volpert. Modelling of Plant Growth with Apical or Basal Meristem. Math. Model. Nat. Phenom., 6 (2), 107-132 (2011).
    HAL preprint  article
  28. P. Kurbatova, S. Bernard, N. Bessonov, F. Crauste, I. Demin, C. Dumontet, S. Fischer, V. Volpert. Hybrid model of erythropoiesis and leukemia treatment with cytosine arabinoside. SIAM J. App. Math., 71 (6), 2246-2268 (2011).
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  29. F. Crauste. A review on local asymptotic stability analysis for mathematical models of hematopoietic with delay and delay-dependent coefficients. Annals of the Tiberiu Popoviciu Seminar of functionnal equations, approximation and convexity, 9, 121-143 (2011).
    HAL preprint  journal
  30. M. Adimy, F. Crauste, A. El Abdllaoui. Boundedness and Lyapunov Function for a Nonlinear System of Hematopoietic Stem Cell Dynamics. Comptes Rendus Mathematique, 348 (7-8), 373-377 (2010).
    HAL preprint  article
  31. M. Adimy, F. Crauste, C. Marquet. Asymptotic behavior and stability switch for a mature-immature model of cell differentiation. Nonlinear Analysis: Real World Applications, 11 (4), 2913-2929 (2010).
    HAL preprint  article
  32. F. Crauste. Stability and Hopf bifurcation for a first-order linear delay differential equation with distributed delay, in Complex Time Delay Systems (Ed. F. Atay), Springer, 1st edition, 320p., ISBN: 978-3-642-02328-6 (2010).
    HAL preprint  book chapter
  33. F. Crauste, I. Demin, O. Gandrillon, V. Volpert. Mathematical study of feedback control roles and relevance in stress erythropoiesis. Journal of Theoretical Biology, 263 (3), 303-316 (2010).
    HAL preprint  article
  34. M. Adimy, F. Crauste, My L. Hbid, R. Qesmi. Stability and Hopf bifurcation for a cell population model with state-dependent delay. SIAM J. Appl. Math, 70 (5), 1611-1633 (2010).
    HAL preprint  article
  35. I. Demin, F. Crauste, O. Gandrillon, V. Volpert. A multi-scale model of erythropoiesis. Journal of Biological Dynamics, 4 (1), 59-70 (2010).
    HAL preprint  article
  36. N. Bessonov, F. Crauste, I. Demin, V. Volpert. Dynamics of erythroid progenitors and erythroleukemia. Mathematical Modeling of Natural Phenomena, 4 (3), 210-232 (2009).
    HAL preprint  article
  37. F. Crauste. Delay Model of Hematopoietic Stem Cell Dynamics: Asymptotic Stability and Stability Switch. Mathematical Modeling of Natural Phenomena, 4 (2), 28-47 (2009).
    HAL preprint  article
  38. M. Adimy, F. Crauste. Mathematical model of hematopoiesis dynamics with growth factor-dependent apoptosis and proliferation regulation. Mathematical and Computer Modelling, 49, 2128-2137 (2009).
    HAL preprint  article
  39. F. Crauste, M.L. Hbid, A. Kacha. A delay reaction-diffusion model of the dynamics of botulinum in fish. Mathematical Biosciences, 216, 17-29 (2008).
    HAL preprint  article
  40. M. Adimy, F. Crauste, A. El Abdllaoui. Discrete maturity-structured model of cell differentiation with applications to acute myelogenous leukemia. Journal of Biological Systems, 16 (3),  395-424 (2008).
    HAL preprint  article
  41. M. Adimy, S. Bernard, J. Clairambault, F. Crauste, S. Génieys, L. Pujo-Menjouet. Modélisation de la dynamique de l'hématopoïèse normale et pathologique. Hématologie, 14 (5), 339-350 (2008).
    HAL preprint
  42. M. Adimy, O. Angulo, F. Crauste, J.C. Lopez-Marcos. Numerical integration of a mathematical model of hematopoietic stem cell dynamics. Computer and Mathematics with Applications, 56, 594-606 (2008).
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  43. F. Crauste, L. Pujo-Menjouet, S. Génieys, C. Molina, O. Gandrillon. Adding Self-Renewal in Committed Erythroid Progenitors Improves the Biological Relevance of a Mathematical Model of Erythropoiesis. Journal of Theoretical Biology, 250, 322-338 (2008).
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  44. M. Adimy, F. Crauste. Modelling and asymptotic stability of  a growth factor-dependent stem cells dynamics model with distributed delay. Discrete and Continuous Dynamical Systems Series B, 8 (1), 19-38 (2007).
    HAL preprint  article
  45. M. Adimy, F. Crauste, A. El Abdllaoui. Asymptotic Behavior of a Discrete Maturity Structured System of Hematopoietic Stem Cells Dynamics with Several Delays. Mathematical Modelling of Natural Phenomena, Vol 1 (2), 1-22 (2006).
    HAL preprint  article
  46. M. Adimy, F. Crauste, S. Ruan. Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases. Bulletin of Mathematical Biology, 68 (8), 2321-2351 (2006).
    HAL preprint  article
  47. M. Adimy, F. Crauste, S. Ruan. Periodic Oscillations in Leukopoiesis Models with Two Delays. Journal of Theoretical Biology, 242, 288-299 (2006).
    HAL preprint  article
  48. F. Crauste. Global Asymptotic Stability and Hopf Bifurcation for a Blood Cell Production Model. Mathematical Biosciences and Engineering, 3 (2), 325-346 (2006).
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  49. M. Adimy, F. Crauste, A. Halanay, M. Neamţu, D. Opriş. Stability of limit cycles in a pluripotent stem cell dynamics model. Chaos, Solitons and Fractals, 27 (4), 1091-1107 (2006).
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  50. M. Adimy, F. Crauste, S. Ruan. A mathematical study of the hematopoiesis process with applications to chronic myelogenous leukemia. SIAM J. Appl. Math., 65 (4), 1328-1352 (2005).
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  51. M. Adimy, F. Crauste, S. Ruan. Stability and Hopf bifurcation in a mathematical model of pluripotent stem cell dynamics. Nonlinear Analysis: Real World Applications, 6 (4), 651-670 (2005).
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  52. M. Adimy, F. Crauste. Existence, positivity and stability for a nonlinear model of cellular proliferation. Nonlinear Analysis: Real World Applications, 6 (2), 337-366 (2005).
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  53. M. Adimy, F. Crauste, L. Pujo-Menjouet. On the stability of a maturity structured model of cellular proliferation. Dis. Cont. Dyn. Sys. Ser. A, 12 (3), 501-522 (2005).
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  54. F. Crauste, M. Adimy. Bifurcation dans un modèle non-linéaire de production du sang. Comptes-rendus de la 7ième Rencontre du Non-Linéaire, Non-Linéaire Publications, Paris, 73-78 (2004).
    HAL preprint
  55. M. Adimy, F. Crauste. Stability and instability induced by time delay in an erythropoiesis model. Monografias del Seminario Matematico Garcia de Galdeano, 31, 3-12 (2004).
    HAL preprint
  56. M. Adimy, F. Crauste. Global stability of a partial differential equation with distributed delay due to cellular replication. Nonlinear Analysis, 54 (8), 1469-1491 (2003).
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  57. M. Adimy, F. Crauste. Un modèle non-linéaire de prolifération cellulaire : extinction des cellules, invariance. Comptes Rendus Mathématiques, 336, 559-564 (2003).
    HAL preprint  article

Habilitation à Diriger des Recherches (HDR): Delay Equations and Models of Cell Population Dynamics.    manuscript

PhD Thesis: Mathematical study of hyperbolic partial differential equations modelling blood cells regulation processes - Applications to periodic hematological diseases.    manuscript (in french)